Investigating the Effects of Chasteberry and Green Tea Extract on Polycystic Ovarian Syndrome Rat Models

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Document Type : Research article

Authors

1 Clinical Laboratory Science, College of Pharmacy, University of Basrah, Basrah, Iraq.

2 Clinical Laboratory Science, University of Basrah, College of Pharmacy, Iraq

3 Animal Production Techniques, Technical Agricultural College of Mosul, Northern Technical University, Iraq

Abstract

Abstract

Polycystic ovarian syndrome is a gynecological disorder that associated with a diverse health issue affecting numerous body system. Therefore, this study conducted to investigate the possible effect of chasteberry and green tea extract in treating polycystic ovary disorder. Twenty-four female rats classified in to four groups. Group I control treated with distilled water. Group II positive control (polycystic ovary) treated with 1mg/kg letrozole orally for 4 weeks. Group III treated with 1mg/kg letrozole orally with 750 mg/kg of chasteberry extract for 4 weeks. Group IV treated with 1mg/kg letrozole orally with 250 mg/kg of green tea extract for 4 weeks. At the end of study periods, all animals sacrificed for hormonal analysis and histopathological evaluation. Hormonal pictures of both extract show a significant (P<0.05) increase in serum follicle stimulating hormone along with significant (P<0.05) reduction in serum prolactin hormone and luteinizing hormone in comparison to positive control group. Microscopically there is a reduction in size and number of ovarian cystic follicle and restoration of normal ovary structure, presence of graafian follicle with their corpora lutea and restoration of ovulation. These finding support the therapeutic potential of chasteberry extract and green tea extract in controlling and management of induced cystic ovary in rat models.

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Assiut Veterinary Medical Journal

Articles in Press, Accepted Manuscript
Available Online from 30 January 2025

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